On July 21, 2025, the Chemical Probes Portal celebrates 10 years since its launch, inspired by the 2015 Nature Chemical Biology paper by Arrowsmith et al. Now featuring 1,163 probes and over 1,600 expert reviews, the Portal empowers researchers with trusted tools and guidance. From classic inhibitors like JQ1 to PROTACs and molecular glues, it supports reproducible, high-impact science. A vital resource for chemical biology, the Portal continues to grow in reach and relevance.

he Chemical Probes Portal now covers 601 protein targets, enhancing resources for chemical biology and drug discovery. New additions include probes for DCTPP1, MASTL, and HCN1, expanding coverage in cancer, neurodegeneration, and targeted protein degradation. The Portal also flags 250+ unsuitable compounds, guiding researchers toward better alternatives. In alignment with Target 2035, it aims to provide a high-quality probe for every human protein by 2035.

The Chemical Probes Hackathon, held on February 20, 2025, at the University of Vienna, brought together PhD students and postdocs to evaluate chemical probes alongside industry and academic experts. Organized by the Chemical Probes Portal and the European Federation for Pharmaceutical Sciences, the event enhanced participants’ understanding of chemical probes and contributed valuable assessments to the Chemical Probes Portal. While challenging for some, it fostered intense scientific discussions between students and experts.