Increasing the quality and robustness of biomedical research using chemical probes.

Welcome to the Chemical Probes Portal, a free, public online resource of expert reviews and evaluations of chemical probes.

The Chemical Probes Portal supports the biological research community to select the best chemical tools such as inhibitors, activators and degraders, to use as chemical probes for their experiments. Its expert panel provides guidance to select the most suitable probe for use in in-vitro and in-vivo experiments and shares experiences in best practice.


The new Chemical Probes Portal is now available at including data and recommendations on more than 650 small molecule tools. The new portal has a faster, more intuitive search, easier online forms for submitting and reviewing compounds and an entirely new backend structure to facilitate updates in the future.

How to cite the Chemical Probes Portal

A manuscript describing the new portal is in preparation, meanwhile please cite the original publication:

  • The promise and peril of chemical probes, Arrowsmith et al Nat Chem Biol 2015 11;536-531. doi: 10.1038/nchembio.1867 ( Nature Chemical Biology)

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