Details of the Chemical Probes Portal, a major, updated online resource to help biomedical researchers use the best small-molecule reagents for their experiments have been published.
Please see and cite our
new publication
describing the enhanced Portal content and processes
Increasing the quality and robustness of biomedical research using chemical probes.
Increasing the quality and robustness of biomedical research using chemical probes.
Welcome to the Chemical Probes Portal, a free, public online resource of expert reviews and evaluations of chemical probes.
The Chemical Probes Portal supports the biological research community to select the best chemical tools such as inhibitors, activators and degraders, to use as chemical probes for their experiments. Its expert panel provides guidance to select the most suitable probe for use in in-vitro and in-vivo experiments and shares experiences in best practice.
News
Experts in biomedical research are calling for better use of chemical probes to improve our understanding of protein function and the foundations on which much of modern drug discovery and development are based.
We’ve added two new features to the Chemical Probes Portal, enabling users to filter and download probe data, as well as search the entire Portal site to find news articles, guidelines and more.
Dr Domenico Sanfelice, the Portal Curator, looks back at recent updates to the Portal including interesting small molecules, new protein targets and changes to the Chemical Probes Portal.
The Chemical Probes Portal now includes structural alerts for PAINS compounds and toxicophores and has published information and advice on their use.
Cite us:
- The Chemical Probes Portal: an expert review-based public public resource to empower chemical probe assessment, selection use, Antolin et al.Nucleic Acids Research 2022 gkac909. doi: 10.1093/nar/gkac909
- Please add our URL to your publication: www.chemicalprobes.org.