ZINC4511851

ZINC4511851 : Inhibitor of DCTPP1

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(0 ratings)

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Probe ZINC4511851 is in the process of SERP review.

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Information

DCTPP1

Inhibitor

up to 5 uM

In Vitro Validations

Uniprot ID: Q9H773

Target Class: Enzyme

Target SubClass: Pyrophosphatase

Potency: IC50

Potency Value: 20 nM

Potency Assay: Enzymatic assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

dCTP pyrophosphatase 1, XTP3TPA, DCTPP1, DCTP1_HUM ...

DOI Reference: 10.1021/acs.jmedchem.6b01786

Uniprot ID: Q9H773

Target Class: Enzyme

Target SubClass: Pyrophosphatase

Potency: ΔTm

Potency Value: 10

Potency Assay: DSF

PDB ID for probe-target interaction (3D structure): --

Target aliases:

dCTP pyrophosphatase 1, XTP3TPA, DCTPP1, DCTP1_HUM ...

DOI Reference: 10.1021/acs.jmedchem.6b01786

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): Selectivity profile for ZINC4511851 toward a small set of NTPases and NUDIX enzymes was assessed.

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SERP ratings and comments

SERP Ratings

In Cell Rating

SERP Comments:

The probe has been well-characterized in biochemical assays and has the highest potency reported to date for this target. However, further validation of target engagement in cells would be needed and a side-by-side comparison to an inactive analogue (e.g., compound 28 from 10.1021/acs.jmedchem.6b01786) would be highly recommended for validation of on-target cellular effects.

(last updated: 10 Mar 2025 )