XMU-MP-2

XMU-MP-2 : Inhibitor of BRK

Structure

SERP Rating

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Information

PTK6

Inhibitor

up to 1 uM

In Vitro Validations

Uniprot ID: Q13882

Target Class: Kinase

Target SubClass: Tyr Kinase

Potency: IC50

Potency Value: 5.4 nM

Potency Assay: Enzymatic kinase assay using HotSpot technology

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Protein-tyrosine kinase 6, BRK, PTK6, PTK6_HUMAN, ...

DOI Reference: 10.1158/0008-5472.CAN-16-1038

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay, off target (cells): XMU-MP-2 exhibited the best activity among 28 tyrosine kinases profiled, suggesting XMU-MP-2 is a potent and selective inhibitor of BRK.

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