VU69

VU69 : Inhibitor of PLD1

Structure

SERP Rating

Probe VU69 is in the process of SERP review.

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Information

PLD1

Inhibitor

up to 200 nM

Probe Availability:

MedChemExpress

In Vitro Validations

Uniprot ID: Q13393

Target Class: Enzyme

Target SubClass: Phospholipase

Potency: IC50

Potency Value: 46 nM

Potency Assay: In vitro PLD activity assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Phospholipase D1, PLD1, PLD1_HUMAN, hPLD1, PLD 1, ...

DOI Reference: 10.1038/nchembio.140

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): In cells, IC50 for PLD2 =1,800 nM (HEK293-gfpPLD2 PLD activity) Selectivity within target family: 20 folds selective against PLD2 Outside target family: it has been reported to inhibit Caspase-1 at 10 uM ( DOI: 10.1038/s41598-019-50806-9)

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SERP ratings and comments

No SERP comments found for VU69