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VIP36 | VIP36 : Agonist of CNR1
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CNR1
  • Ki:22 nM
  • EC50:2.17 nM
  • EC50:25.44 nM
up to 100 nM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
Functional selectivity for CB1 over CB2 receptors was also confirmed by in-cell cAMP and biochemical ...
In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selectivity over a broad range of targets was tested in binding assays (approximately 45 CNS targets ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
No measurable potency and low efficacy were observed in BRET Gi1 assays on MOR. No measurable effica ...

Potency
Cellular
In Vitro

CNR1

Mode of Action: Agonist

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/s41586-025-08618-7

In Vivo Validations

Mouse
Dose: 3 mg/Kg
Route of delivery: Intraperitoneal

DOI Reference: 10.1038/s41586-025-08618-7

Chemical Information

Molecular Formula C27H35FN6O4
SMILEs COC(=O)[C@@H](NC(=O)c1nn(Cc2ccc(F)cc2)c2cc(OCCCCNC(=N)N)ccc12)C(C)(C)C
InChI InChI=1S/C27H35FN6O4/c1-27(2,3)23(25(36)37-4)32-24(35)22-20-12-11-19(38-14-6-5-13-31-26(29)30)15-21(20)34(33-22)16-17-7-9-18(28)10-8-17/h7-12,15,23H,5-6,13-14,16H2,1-4H3,(H,32,35)(H4,29,30,31)/t23-/m1/s1
Molecular weight 526.27 Da
AlogP 3.183270000000001
HBond acceptors 10
HBond donors 5
Atoms 73

Expert Reviews

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