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URMC-099

Inhibitor of MAP3K9, MAP3K10, MAP3K11

Structure

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Information

Protein target names: MAP3K9, MAP3K10, MAP3K11

Mechanism of action: Inhibitor

Primary References:

In Vitro Validations

Uniprot ID: P80192
Target Class: Kinase
Target SubClass: TKL
Potency: IC 50
Potency Value: 19 nM
Potency Assay: Kinase assay
PDB ID for probe-target interaction (3D structure): --
Structure-activity relationship: In our SAR studies, we observed that the pyrrolo NH and the pyridine nitrogen of the scaffold were required for potency. In addition, for the side chains, having an aromatic group such as an indole, aniline, or phenol was associated with high in vitro enzyme inhibition potency as they provided a hydrogen bond donor from the para position of an aromatic ring.
Target aliases:
Mitogen-activated protein kinase kinase kinase 9, ...

DOI Reference: 10.1021/jm401094t

In Cell Validations

In Vivo Data

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SERP ratings and comments

SERP Ratings

In Cell Rating
In Model Organisms

SERP Comments:

This is a promiscuous kinase inhibitor with significant off-target activity.

(last updated: 20 Jun 2016 )

SERP Ratings

In Cell Rating
In Model Organisms

SERP Comments:

This compound is an orally bioavailable, brain-penetrant inhibitor of MLK, but it show poor selectivity against many other protein kinases.

(last updated: 24 Jun 2016 )

SERP Ratings

In Cell Rating
In Model Organisms

SERP Comments:

This probe is not very selective for MLK3. A large number of other kinases are significantly inhibited by this probe.

(last updated: 1 Jul 2016 )

SERP Comments:

This compound is rather promiscuous and targets several kinases other than the MLK family with equal or even greater potency.

(last updated: 5 Jul 2016 )