Tozasertib
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Non selective compound
Broad specificity kinase inhibitor: Tozasertib binds many kinases in addition to the primary target that are not in the same subgroup as the primary target (Selectivity score [Kd off-target/Kd primary target]=0.0314). Karaman et al., 2008. Nat. Biotech. 26, 127-132.