Ricolinostat
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Portal Comments
This drug has been extensively studied by a number of labs. Sheltzer's Lab published a paper in 2019 in which they knocked out HDAC6 from multiple cancer cell lines, and observed that ricolinostat still killed the HDAC6-KO cells with no loss in potency. The cytotoxic effects of ricolinostat are entirely independent of HDAC6 inhibition (10.1126/scitranslmed.aaw841).