NSC19630
NSC19630
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Unsuitable
Intended target: WRN helicase
A 2024 publication by Heuser A. et al reports that previously published WRN Helicase inhibitors (ML216, NSC19630 or NSC617145) were characterized in an extensive set of biochemical and biophysical assays and could be ruled out as specific WRN helicase probes. DOI: 10.1002/cmdc.202300613