LDN-57444
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Non selective compound
- Intended target, UCHL1: considered de facto a chemical probe for UCHL1 in early 2000's, recent publications have reported LDN-57444 to have liabilities including off-target toxicity and chemical instability (DOI: 10.1002/cbic.201900434). LDN-57444 has also been proved to be inactive against UCHL1 in cells. (DOI: 10.1021/jacs.0c04527).