GW-5074
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Non binding compound
Intended Target LC3: Although previously reported to bind LC3, recent findings by Schwalm et al. (2024) demonstrate that this compound does not bind LC3 at all. Therefore, it should not be used as a chemical probe to study LC3. (DOI: 10.1038/s41467-024-54409-5, Do They Even Bind?)