DT-061
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Toxic compound
DT-061 was initially described as a small-molecule compound described activator of protein phosphatase 2A (PP2A). A newly published chemoproteomics profiling suggests that DT-061 toxicity is due to the disruption of Golgi and ER structures and lipid synthesis associated with these structures and no direct effects on PP2A complex could be established 10.15252/embj.2022110611.