UNC8732

UNC8732 : Degrader (PROTAC) of NSD

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(0 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe UNC8732 is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Information

NSD2

Degrader (PROTAC)

up to 2 uM

Additional Data

SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: O96028

Target Class: Epigenetic

Target SubClass: Methyltransferase

Potency: Kd

Potency Value: 71 ± 4 nM

Potency Assay: SPR

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Histone-lysine N-methyltransferase NSD2, WHSC1, TR ...

DOI Reference: 10.1038/s41589-024-01660-y

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay, off target (cells): Global proteomic of U2OS cells was used to assess selectivity up to 10 uM for both UNC8732 and UNC8884

I have extra information to add

SERP ratings and comments

SERP Ratings

In Cell Rating

SERP Comments:

UNC8732 is a prodrug with the requirement of 10% FBS for its full activity. NC8732 is not active in FBS-low medium such as Opti-MEM.

(last updated: 21 Aug 2025 )