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UNC8732

UNC8732 : Degrader (PROTAC) of NSD

Structure

Information

  • NSD2
  • Degrader (PROTAC)
  • up to 2 uM

In Vitro Validations

Uniprot ID: O96028
Target Class: Epigenetic
Target SubClass: Methyltransferase
Potency: Kd
Potency Value: 71 ± 4 nM
Potency Assay: SPR
PDB ID for probe-target interaction (3D structure): --
Target aliases:
Histone-lysine N-methyltransferase NSD2, WHSC1, TR ...

DOI Reference: 10.1038/s41589-024-01660-y

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay, off target (cells): Global proteomic of U2OS cells was used to assess selectivity up to 10 uM for both UNC8732 and UNC8884
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SERP ratings and comments

No SERP comments found for UNC8732