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UNC8209 | UNC8209 : Degrader (PROTAC) of TBK1
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
TBK1
    • DC50:80 ± 20 nM
    • DC50:23 ± 5 nM
    Degrader (PROTAC)
    up to 1 uM

    Selectivity

    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    Western Blot of cell lysate
    Selectivity Assessment Description:
    UNC8209 displayed high selectivity for TBK1 degradation over its homolog IKKε, a common off-target o ...
    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    To evaluate the selectivity of UNC8209, global proteomic profiling in UMRC2 cells treated with 1 μM ...
    Selectivity Assessment Description:
    Mass spectrometry analysis identified and quantified 8,307 proteins. Of these, 16 proteins were sign ...

    Potency
    Cellular
    In Vitro

    TBK1

    Mode of Action: Degrader (PROTAC)

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1016/j.chembiol.2026.03.013

    In Vivo Validations

    Mouse
    Dose: 10 mg/Kg
    Route of delivery: Intraperitoneal
    Cmax: 2300 ng/mL
    Tmax: 2 h

    DOI Reference: 10.1016/j.chembiol.2026.03.013

    Negative Control Compounds

    UNC8461
    Notes: The negative control UNC8461 (NEG) compound failed to reduce TBK1 protein levels.
    SMILES: CN(C(C1CCC1)=O)CCCNC2=NC(NC3=CC=C(OCCOCCOCCOCCOCCOCCCOC4=C5C(C(N(C5=O)C6CCC(N(C)C6=O)=O)=O)=CC=C4)C=C3)=NC=C2Br

    Chemical Information

    Coming Soon...

    References

    Publications

    Cross References

    Expert Reviews

    No SERP comments found for UNC8209

    Probe UNC8209 is in the process of SERP review.

    Please continue to check back for new reviews and commentary.