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UNC0642 | UNC0642 : Inhibitor of EHMT2 and EHMT1
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
EHMT2
  • Ki:3.7 nM
  • IC 50:110 nM
EHMT1
  • IC 50:<2.5 nM
  • IC 50:110 nM
Inhibitor
100 nM - 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
UNC0642 was 2,000-fold selective for the targets over EZH2/PRC2 and 20,000-fold over 15 other protei ...
Selectivity Assessment Description:
UNC0642 was 2,000-fold selective for the targets over EZH2/PRC2 and 20,000-fold over 15 other prote ...

Potency
Cellular
In Vitro

EHMT2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jm401480r

EHMT1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jm401480r

In Vivo Validations

Mouse
Dose: 5 mg/kg
Route of delivery: Intraperitoneal
Organ of interest (O): brain

DOI Reference: 10.1021/jm401480r

Orthogonal Probes def

UNC0638
BIX-01294
A-366

Chemical Information

Molecular Formula C29H44F2N6O2
SMILEs COc1cc2c(NC3CCN(C(C)C)CC3)nc(N3CCC(F)(F)CC3)nc2cc1OCCCN1CCCC1
InChI InChI=1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34)
Molecular weight 546.35 Da
AlogP 5.0233
HBond acceptors 8
HBond donors 1
Atoms 83

References

Publications

Cross References

canSARChEMBLBindingDBGDSC1

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

by SERP
(on 17 Oct 2016)
Cellular Use Rating
In Model Organisms
UNC0642 potently and specifically inhibits G9a and GLP compared with a wide range of pharmacologically important proteins (except for the histamine H3 receptor) in cell-free assays. Importantly, the...
by SERP
(on 21 Jan 2017)
Cellular Use Rating
In Model Organisms
The in vitro potency and selectivity against other family members is good. The margin between concentrations that yield a functional effect and cellular toxicity was determined and is at least 80-fold....
by SERP
(on 18 Jun 2017)
Cellular Use Rating
In Model Organisms
This is a well characterised probe with dual activity against the related targets GLP and G9a. The probe has been evaluated for selectivity against a variety of off-targets including kinases, GPCRs,...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria