UCPH-101

UCPH-101 : Inhibitor of SLC1A3

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(0 ratings)

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Probe UCPH-101 is in the process of SERP review.

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Information

SLC1A3

Inhibitor

up to 10 uM

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay, off target (cells): Selectivity within target family: The compound did not display any significant inhibition of the Glu-induced responses in EAAT2- or EAAT3-cells at concentrations up to 100 μM.

Potency assay, off target (cells): The functional properties of UCPH-101 were characterized by patch-clamp electrophysiology on tsA201 cells expressing human EAAT1, rat EAAT4, and mouse EAAT5, and proved that UCPH-101 is selective also against the other family members. (DOI: 10.1523/JNEUROSCI.3396-12.2013)

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SERP ratings and comments

SERP Ratings

In Cell Rating

SERP Comments:

UCPH-101 is an inhibitor of EAAT1/SLC1A3. Humans have five members in this excitatory amino acid transporter family (EAAT1-5). UCPH-101 shows >450-fold selectivity over human EAAT2 and EAAT3. Selectivity of >29-fold over rat EAAT4 and mouse EAAT5 was also shown, but data for human EAAT4 and EAAT5 is lacking.

(last updated: 6 Mar 2025 )