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U18666A | Inhibitor of NPC1
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NPC1
    • Ki:30 nM
    Inhibitor
    0.1-1 uM

    Selectivity

    Potency
    Cellular
    In Vitro

    NPC1

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.7554/eLife.12177

    In Vivo Validations

    Rat
    Dose: 10 mg/Kg
    Route of delivery: Subcutaneous

    Reference: --

    Negative Control Compounds

    Compound A
    Notes: Ki 4500 nM

    Chemical Information

    Molecular Formula C25H42ClNO2
    SMILEs CCN(CC)CCO[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]32)C1.Cl
    InChI InChI=1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-11-13-24(3)18(17-19)7-8-20-21-9-10-23(27)25(21,4)14-12-22(20)24;/h7,19-22H,5-6,8-17H2,1-4H3;1H/t19-,20-,21-,22-,24-,25-;/m0./s1
    Molecular weight 423.29 Da
    AlogP 5.667100000000007
    HBond acceptors 3
    HBond donors --
    Atoms 71

    References

    Publications

    Cross References

    ChEMBL PubChem PubChem ChEBI canSAR

    Vendors

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    Expert Reviews

    by SERP
    (on 13 Mar 2021)
    Cellular Use Rating
    In Model Organisms
    More data is needed for this compound to judge it as a probe. No panel data is provided neither within target family nor outside. Crosslinking experiments have identified the proposed target. Analogues...
    by SERP
    (on 13 Mar 2021)
    Cellular Use Rating
    In Model Organisms
    With very little characterization, it is difficult to judge the quality of this compound. There is no selectivity screening and only a single on-target cellular assay. The data has not been validated...
    by SERP
    (on 20 Mar 2021)
    Cellular Use Rating
    In Model Organisms
    U18666A is a chemical probe for NPC1 that transports cholesterol from the lysosomal membrane. In cells U18666A inhibits cholesterol transesterification and SREBP2 processing at nM concentrations. U18666A...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria