TTBK1-IN-2

TTBK1-IN-2 : Inhibitor of TTBK1

Structure

SERP Rating

Probe TTBK1-IN-2 is in the process of SERP review.

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Information

TTBK1

Inhibitor

up to 5 uM

Probe Availability:

MedChemExpress

In Vitro Validations

Uniprot ID: Q5TCY1

Target Class: Kinase

Target SubClass: CK1

Potency: IC50

Potency Value: 240 nM

Potency Assay: Biochemical assay

PDB ID for probe-target interaction (3D structure): 7QHW

Target aliases:

Tau-tubulin kinase 1, KIAA1855, BDTK, TTBK1, TTBK1 ...

DOI Reference: 10.1021/acs.jmedchem.1c01942

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Selective against TTBK2 with IC50 4220 nM. TTBK1-IN-2 was screened at a fixed concentration of 10 μM against more than 20 different kinases with a selectivity score (S35) of 0.04.

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SERP ratings and comments

No SERP comments found for TTBK1-IN-2