TL13-112
TL13-112 : Degrader (PROTAC) of ALK
Structure
Probe TL13-112 is in the process of SERP review.
Please continue to check back for new reviews and commentary.
Information
Protein target names: ALK
Mechanism of action: Degrader (PROTAC)
Recommended in-cell concentration:
250 nM, up to 1 uM
Primary References:
Probe Availability:
In Vitro Validations
Uniprot ID: Q9UM73
Target Class:
Kinase
Target SubClass: RTK
Potency: IC50
Potency Value: 0.6 nM
Potency Assay: ALK LANCE Activity Assay at ATP Km (18µM)
PDB ID for probe-target interaction (3D structure):
--
Structure-activity relationship:
no
Target aliases:
ALK tyrosine kinase receptor, ALK, ALK_HUMAN, Anap ...
DOI Reference: 10.1021/acs.jmedchem.7b01655
In Cell Validations
In Vivo Data
No in Vivo Validations
SERP ratings and comments
No SERP comments found for TL13-112