TL13-112

TL13-112 : Degrader (PROTAC) of ALK

Structure

Information

Protein target names: ALK

Mechanism of action: Degrader (PROTAC)

Recommended in-cell concentration:
250 nM, up to 1 uM

In Vitro Validations

Uniprot ID: Q9UM73
Target Class: Kinase
Target SubClass: RTK
Potency: IC50
Potency Value: 0.6 nM
Potency Assay: ALK LANCE Activity Assay at ATP Km (18µM)
PDB ID for probe-target interaction (3D structure): --
Structure-activity relationship: no
Target aliases:
ALK tyrosine kinase receptor, ALK, ALK_HUMAN, Anap ...

DOI Reference: 10.1021/acs.jmedchem.7b01655

In Cell Validations

In Vivo Data

No in Vivo Validations

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SERP ratings and comments


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