TL02-59 |
TL02-59 : Inhibitor of FGR, LYN
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| FGR |
|
|
| LYN |
|
up to 100 nM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
TL02-59 was profiled against 456 kinases in the KINOMEscan analysis, a kinome-wide competition assa ...
Selectivity Assessment Description:
TL02-59 interacted with 23 of the 456 kinases tested for a selectivity (S) score of 0.07. Most of th ...
Potency Cellular
In Vitro
FGR
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? No
DOI Reference: 10.1021/acschembio.8b00154
LYN
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? No
DOI Reference: 10.1021/acschembio.8b00154
In Vivo Validations
Mouse
Dose: 2 mg/Kg
Route of delivery:
Intravenous
Plasma half life:
5.7 h
Systemic clearance:
13.2 mL/min/Kg
Cmax:
1178 ng/mL
Area Under the Curve::
2456 h*ng/mL
Volume of Distribution at Steady-State:
4.7 L/Kg
DOI Reference: 10.1021/acschembio.8b00154
Dose: 10 mg/Kg
Route of delivery:
Oral
Plasma half life:
6.5 h
Cmax:
695 ng/mL
Tmax:
1.00 h
Area Under the Curve::
7712 h*ng/mL
Bioavailability:
59%
DOI Reference: 10.1021/acschembio.8b00154
Chemical Information
| Molecular Formula | C32H34F3N5O4 |
| SMILEs | CCN1CCN(Cc2ccc(/N=C(\O)c3ccc(C)c(Oc4ncnc5cc(OC)c(OC)cc45)c3)cc2C(F)(F)F)CC1 |
| InChI | InChI=1S/C32H34F3N5O4/c1-5-39-10-12-40(13-11-39)18-22-8-9-23(15-25(22)32(33,34)35)38-30(41)21-7-6-20(2)27(14-21)44-31-24-16-28(42-3)29(43-4)17-26(24)36-19-37-31/h6-9,14-17,19H,5,10-13,18H2,1-4H3,(H,38,41) |
| Molecular weight | 609.26 Da |
| AlogP | 6.540320000000007 |
| HBond acceptors | 9 |
| HBond donors | 1 |
| Atoms | 78 |