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THPP-1 | Inhibitor of PDE10A
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
PDE10A
  • Ki:0.99 nM
  • IC50:49 nM
50-200 nM
10 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
PDE selectivity: closest hit is PDE6A (44 fold)
In Cell Selectivity Assessment
Selectivity Assessment Description:
Closest off-targets (Panlabs): Adenosine transporter (guinea pig): IC50 = 1.61 µM @ 10 µM

Potency
Cellular
In Vitro

PDE10A

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1016/j.bmcl.2012.07.072

In Vivo Validations

Rat, Dog, Monkey
Dose: 1-10 mg/Kg
Route of delivery: Oral
Plasma half life: 1.2 (R), 7.2 (D), 7.7 (M) h
Systemic clearance: 6.0 (R), 3.8 (D), 7.7(M) mL/min/kg
Bioavailability: 47% (R), 79% (D), 31% (M)
Organ of interest (O): Brain
Target engagement assay: Rat 6.0 1.4 47 Dog 3.8 7.2 79 Monkey 7.7 1.4 31

DOI Reference: 10.1016/j.bmcl.2012.07.072

Negative Control Compounds

THPP-1-NC

Chemical Information

Molecular Formula C23H21ClN6O3
SMILEs COCCOc1nc(-c2ccc(Cl)nc2)nc2c1CN(C(=O)c1ncn3ccccc13)CC2
InChI InChI=1S/C23H21ClN6O3/c1-32-10-11-33-22-16-13-29(23(31)20-18-4-2-3-8-30(18)14-26-20)9-7-17(16)27-21(28-22)15-5-6-19(24)25-12-15/h2-6,8,12,14H,7,9-11,13H2,1H3
Molecular weight 464.14 Da
AlogP 3.0634000000000015
HBond acceptors 9
HBond donors --
Atoms 54

Vendors

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Expert Reviews

by SERP
(on 12 Oct 2020)
Cellular Use Rating
In Model Organisms
THPP-1 is a high quality, selective and potent probe to study PDE10A inhibition in vitro or in vivo. It demonstrated in vivo target engagement and efficacy at a dose (10 mg/kg) that is well tolerated in...
by SERP
(on 12 Oct 2020)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria