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THNAN69

THNAN69 : Degrader (PROTAC) of LIMK2

Structure

Information

  • LIMK2
  • Degrader (PROTAC)
  • 10-100 nM

In Vitro Validations

Uniprot ID: P53671
Target Class: Kinase
Target SubClass: TKL
Potency: Kd
Potency Value: 249 nM
Potency Assay: SPR
PDB ID for probe-target interaction (3D structure): --
Target aliases:
LIM domain kinase 2, LIMK2, LIMK2_HUMAN, LIMK-2

Other Reference: Peer Reviewed at SGC

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay, off target (cells): Selectivity against LIMK1 assessed via NanoBRET EC50 412 nM
Potency assay, off target (cells): Full cellular (MOLT4) proteomics shows no significant degradation of other targets.
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SERP ratings and comments

No SERP comments found for THNAN69