THIQ

THIQ : Agonist of MC4R

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(2 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe THIQ is in the process of SERP review.

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Information

MC4R

Agonist

up to 1 uM

Probe Availability:

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Cell:

Selectivity within target family: low potency at human MC1R, MC3R and MC5R with IC50s of 2067, 761, 326 nM and EC50s of 2850, 2487, and 737 nM, respectively.

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 12 Nov 2022 )

SERP+ Ratings

In Cell Rating

In Model Organisms

SERP+ Comments:

This compound shows a good selectivity within MC4R family and is accompanied by a suitable inactive control compound. Selectivity has been assessed in a small panel of off-targets. It shows a clear dose-dependent activity in vivo, but unfortunately no CNS targeting data.

(last updated: 14 Oct 2025 )