TASIMELTEON

TASIMELTEON : Agonist of MTNR1A and MTNR1B

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(0 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe TASIMELTEON is in the process of SERP review.

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Information

MTNR1A
MTNR1B

Agonist

up to 100 nM

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): No significant responses (≥50% inhibition or stimulation) were observed in any radioligand receptor binding assay and enzyme assays, except for both melatonin receptors MT1 and MT2.

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SERP ratings and comments

SERP Ratings

In Cell Rating

SERP Comments:

This is an approved drug, which is active on both MT1 and MT2. It is a very potent and selective compound.

(last updated: 7 Apr 2025 )

SERP Ratings

In Cell Rating

(last updated: 1 May 2025 )