Takinib |
Takinib : Inhibitor of MAP3K7
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| MAP3K7 |
|
|
up to 5 µM
Selectivity
In Vitro Selectivity Assessment
IRAK4
Gene ID: Q9NWZ3
Organism: Homo sapiens
Family: TKL Ser/Thr protein kinase family
Potency: IC50 - 120 nM
Selectivity Assessment Description:
Screened at 10 µM against 140 kinases, Dundee Selectivity Profiling. Closest targets >90% of control ...
Potency Cellular
In Vitro
MAP3K7
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1016/j.chembiol.2017.07.011
In Vivo Validations
Mouse
Dose: 50 mg/kg
Route of delivery:
Intraperitoneal
Plasma half life:
0.2566 h
DOI Reference: 10.1016/j.chembiol.2017.07.011
Chemical Information
| Molecular Formula | C18H18N4O2 |
| SMILEs | CCCn1c(/N=C(\O)c2cccc(C(=N)O)c2)nc2ccccc21 |
| InChI | InChI=1S/C18H18N4O2/c1-2-10-22-15-9-4-3-8-14(15)20-18(22)21-17(24)13-7-5-6-12(11-13)16(19)23/h3-9,11H,2,10H2,1H3,(H2,19,23)(H,20,21,24) |
| Molecular weight | 322.14 Da |
| AlogP | 3.9659700000000013 |
| HBond acceptors | 6 |
| HBond donors | 3 |
| Atoms | 42 |