Tacrolimus

FKBP-Tacrolimus inhibitor complex, Molecular Glue of FKBP1A

Structure

Information

Protein target names: FKBP1A

Mechanism of action: FKBP-Tacrolimus inhibitor complex, Molecular Glue

Recommended in-cell concentration:
up to 1 uM

In Vitro Validations

Uniprot ID: P62942
Target Class: Other
Target SubClass: Immunophilin Protein Family
Potency: Kd
Potency Value: 0.4 nM
Potency Assay: Spectrophotometric Assay (Fisher Assay)
PDB ID for probe-target interaction (3D structure): 1FKF
Structure-activity relationship: No
Target aliases:
Peptidyl-prolyl cis-trans isomerase FKBP1A, FKBP12 ...

DOI Reference: 10.1073/pnas.89.9.3686

In Cell Validations

In Vivo Data

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SERP Ratings

In Cell Rating
In Model Organisms

(last updated: 10 Jan 2022 )

SERP Ratings

In Cell Rating
In Model Organisms

(last updated: 11 Jan 2022 )