T863

T863 : Inhibitor of DGAT1

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

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Probe T863 is in the process of SERP review.

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Information

DGAT1

Inhibitor

up to 100 nM

Probe Availability:

In Vitro Validations

Uniprot ID: O75907

Target Class: Enzyme

Target SubClass: Acyltransferase

Potency: IC50

Potency Value: 15 nM

Potency Assay: Biochemical assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Diacylglycerol O-acyltransferase 1, DGAT, AGRP1, D ...

DOI Reference: 10.1021/jm801507v

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selective against DGAT2: 3.7 %inhibition @ 10 uM compound and ACAT-1 IC50 = 12000 nM

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

Caution should be taken that the reported bioavailability is based on the acyl glucuronide metabolite and not the parent compound.

(last updated: 14 Jun 2022 )