T0901317
Agonist of NR1H2, NR1H3
Structure
In Cells
In Model Organisms
SERP ratings and comments
SERP Ratings
SERP Comments:
Probe is highly specific for LXR amongst all steroid hormone receptors tested. Agonist is able to activate LXR target genes and reporters in cell lines and in mice.
(last updated: 15 Sept 2020 )
SERP Ratings
SERP Comments:
T 0901317 is a widely used chemical probe for LXRa/LXRb. It has good potency and selectivity across the nuclear hormone receptor family if used at the appropriate concentrations (maximum 1uM in cells). At high micromolar concentrations, cross-reactivity has been noted on RORa doi: 10.1124/mol.109.060905. T 0901317 can be used as an in vivo chemical probe by oral administration in mice and rats.
(last updated: 4 Nov 2020 )
SERP Ratings
SERP Comments:
T0901317 is a selective probe for LXRα and LXRβ. Although there is no data for selectivity outside of the target family, selectivity across the nuclear hormone receptor family is good within appropriate concentrations (see RORα/γ as exceptions). The probe may also exert acute effects nongenomic in nature and alterations in β-Cell function should be considered at higher concentrations, DOI: 10.1210/en.2016-1941.
(last updated: 4 May 2021 )