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T-50301 | T-50301 : Inhibitor of USP25, USP28
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Names: T-10531, T-50301, cpd 42

Targets Biochemical/Biophysical Potency Cellular Potency
USP25
  • IC50:30 nM
  • ΔTm:7.0 K
  • Kd:200 nM
  • IC50:43 nM
  • IC50:40 nM
USP28
  • IC50:120 nM
  • ΔTm:3.8 K
  • Kd:60 nM
  • IC50:158 nM
  • IC50:60 nM
Inhibitor
up to 1 uM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
Selectivity over other cysteine-DUB family members was assessed via Western Blot of HeLa cells.

Potency
Cellular
In Vitro

USP25

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.5c03045

USP28

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.5c03045

Negative Control Compounds

T-10507
Notes: Cpd 33 (T-10507) had no significant binding in the ITC assay and was found to be inactive in the cellular assay.

Orthogonal Probes def

FT206

Chemical Information

Coming Soon...

References

Publications

Cross References

Expert Reviews

No SERP comments found for T-50301

Probe T-50301 is in the process of SERP review.

Please continue to check back for new reviews and commentary.