SJ6986

SJ6986 : Molecular Glue of GSPT1, GSPT2

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

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Probe SJ6986 is in the process of SERP review.

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Information

GSPT1
GSPT2

Molecular Glues

up to 100 nM

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay, off target (cells): Proteome-wide selectivity was assessed performing multiplexed mass spectrometry-based proteomic analysis in MV4-11 cells upon 4 h of drug or DMSO treatment. Out of the 8927 quantified proteins, SJ6986 reduced most potently and selectively abundance of GSPT1 and GSPT2.

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 3 Jun 2025 )