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SGK1-IN-4 | SGK1-IN-4 : Inhibitor of SGK1
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
SGK1
  • IC50:1 nM
  • IC50:3 nM
  • IC50:50 nM
up to 100 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Compound was tested against the 60 kinases at 0.1 µM concentration and 2Km ATP concentration. Only ...

Potency
Cellular
In Vitro

SGK1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.1c01601

Chemical Information

Molecular Formula C23H21ClFN5O4S
SMILEs O=S(=O)(Nc1ccc(-c2nc(OC3CCC(O)CC3)c3c[nH]nc3n2)cc1)c1cc(Cl)ccc1F
InChI InChI=1S/C23H21ClFN5O4S/c24-14-3-10-19(25)20(11-14)35(32,33)30-15-4-1-13(2-5-15)21-27-22-18(12-26-29-22)23(28-21)34-17-8-6-16(31)7-9-17/h1-5,10-12,16-17,30-31H,6-9H2,(H,26,27,28,29)
Molecular weight 517.10 Da
AlogP 4.295500000000002
HBond acceptors 9
HBond donors 3
Atoms 56

Expert Reviews

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