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SGC-UBD253 | SGC-UBD253 : Inhibitor of HDAC6
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
HDAC6
  • Kd:84 nM
  • Kd:80 nM
  • IC50:95 nM
  • EC50:1900 ± 600 nM
Inhibitor
up to 10 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Using sequence alignment of Zf-UBD pocket, 10 UBD-containing proteins in addition to HDAC6 were puri ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
NanoBRET assay was designed to assess USP16-ISG15 interaction. Similar to the HDAC6 NanoBRET assay, ...

Potency
Cellular
In Vitro

HDAC6

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.3c00314

Negative Control Compounds

CANSAR3935392
Notes: SGC-UBD253N is a closely related negative control with KD = 32 micromolar (SPR).

Chemical Information

Molecular Formula C21H20ClN3O5
SMILEs COc1ccccc1CNC(=O)Cn1c(CCC(=O)O)nc2c(Cl)cccc2c1=O
InChI InChI=1S/C21H20ClN3O5/c1-30-16-8-3-2-5-13(16)11-23-18(26)12-25-17(9-10-19(27)28)24-20-14(21(25)29)6-4-7-15(20)22/h2-8H,9-12H2,1H3,(H,23,26)(H,27,28)
Molecular weight 429.11 Da
AlogP 0.0
HBond acceptors 8
HBond donors 2
Atoms 50

Expert Reviews

by SERP+
(on 23 Sept 2024 )
Cellular Use Rating
SGC-UBD253 can be a useful orthogonal tool for exploring HDAC6. It also has a negative control compound, which can be very helpful. However, further cellular characterization is still necessary. It should...
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