Inhibitor of SMARCA2, SMARCA4, PBRM1



Protein target names: SMARCA2, SMARCA4, PBRM1

Mechanism of action: Inhibitor

Recommended in-cell concentration:
up to 10 uM

In Vitro Validations

Uniprot ID: P51531
Target Class: Epigenetic
Target SubClass: Bromodomain
Potency: Kd
Potency Value: 35 nM
Potency Assay: ITC
PDB ID for probe-target interaction (3D structure): --
Structure-activity relationship: yes
Target aliases:
Probable global transcription activator SNF2L2, SN ...

DOI Reference: 10.1021/acs.jmedchem.0c01242

In Cell Validations

In Vivo Data

No in Vivo Validations

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SERP ratings and comments

SERP Ratings

In Cell Rating

(last updated: 29 Mar 2021 )

SERP Ratings

In Cell Rating

SERP Comments:

SGC-SMARCA-BRDVIII and control compound SGC-BRDVIII-NC comprise high quality small molecules for the evaluation of the inhibition of SMARCA2/4 and PBRM1.

(last updated: 10 Apr 2021 )