SGC-SMARCA-BRDVIII

Inhibitor of SMARCA2, SMARCA4, PBRM1

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(0 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe SGC-SMARCA-BRDVIII is in the process of SERP review.

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Information

Protein target names: SMARCA2, SMARCA4, PBRM1

Mechanism of action: Inhibitor

Recommended in-cell concentration:

up to 10 uM

Primary References:

Aditional Data

SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: P51531

Target Class: Epigenetic

Target SubClass: Bromodomain

Potency: Kd

Potency Value: 35 nM

Potency Assay: ITC

PDB ID for probe-target interaction (3D structure): --

Structure-activity relationship: yes

Target aliases:

Probable global transcription activator SNF2L2, SN ...

DOI Reference: 10.1021/acs.jmedchem.0c01242

In Cell Validations

In Vivo Data

No in Vivo Validations

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SERP ratings and comments

SERP Ratings

In Cell Rating

(last updated: 29 Mar 2021 )

SERP Ratings

In Cell Rating

SERP Comments:

SGC-SMARCA-BRDVIII and control compound SGC-BRDVIII-NC comprise high quality small molecules for the evaluation of the inhibition of SMARCA2/4 and PBRM1.

(last updated: 10 Apr 2021 )