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SB02024 | SB02024 : ATP competitive of PIK3C3
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
PIK3C3
  • Kd:1.1 nM
  • IC50:5 nM
  • IC50:14 nM
  • IC50:5.7 nM
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
SB02024 was tested on the KINOMEscan™ platform (DiscoverX, Fremont, CA). SB02024 was tested at 1 μM ...

Potency
Cellular
In Vitro

PIK3C3

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1016/j.canlet.2018.07.028

In Vivo Validations

Mouse
Dose: 9 or 29 mg/Kg
Route of delivery: Intravenous, Oral
Plasma half life: 1.15 h
Systemic clearance: 26 mL/min/Kg
Bioavailability: 96%
Volume of Distribution at Steady-State: 2.53 L/Kg

DOI Reference: 10.1002/1878-0261.13619

Orthogonal Probes def

VPS34-IN-4
SAR405

Chemical Information

Molecular Formula C16H22F3N3O2
SMILEs C[C@@H]1COCCN1c1cc(N2CCCC[C@@H]2C(F)(F)F)[nH]c(=O)c1
InChI InChI=1S/C16H22F3N3O2/c1-11-10-24-7-6-21(11)12-8-14(20-15(23)9-12)22-5-3-2-4-13(22)16(17,18)19/h8-9,11,13H,2-7,10H2,1H3,(H,20,23)/t11-,13-/m1/s1
Molecular weight 345.17 Da
AlogP 2.5212000000000003
HBond acceptors 5
HBond donors 1
Atoms 46

Expert Reviews

No SERP comments found for SB02024

Probe SB02024 is in the process of SERP review.

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