SB-714786

SB-714786 : Antagonist of HTR1D

Structure

SERP Rating

In Cells

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Probe SB-714786 is in the process of SERP review.

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Information

HTR1D

Antagonist

100 nM

Probe Availability:

MedKoo

In Vitro Validations

Uniprot ID: P28221

Target Class: GPCR

Target SubClass: Serotonin Receptor

Potency: Ki

Potency Value: 0.8 nM

Potency Assay: Radioligand binding assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

5-hydroxytryptamine receptor 1D, HTRL, HTR1DA, HTR ...

DOI Reference: 10.1021/jm049039v

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

In Vitro cross-screening characterization against cloned human receptors: 5-HT1E, 1F, 2A, 2B, 2C, 4, 5A, 6, 7, adrenergic α1B, β2, dopamine D2, D3, D4 reporting high selectivity with at least 250-fold separation over all of the 16 other receptors studied.

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SERP Ratings

In Cell Rating

(last updated: 16 Aug 2022 )