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S9-A13 | S9-A13 : Inhibitor of SLC26A9
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
SLC26A9
    • IC50:90.9 ± 13.4 nM
    • IC50:171.5 ± 34.7 nM
    up to 5 uM

    Selectivity

    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    High concentration (10 μM) of S9-A13 did not affect the Cl−/I− exchange activity of SLC26A3 and SLC2 ...

    Potency
    Cellular
    In Vitro

    SLC26A9

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1096/fj.202200313RR

    Chemical Information

    Molecular Formula C20H18ClN3O2S
    SMILEs Cc1ccc(C(=O)C2CC(=O)Nc3c2c(C)nn3-c2ccc(C)c(Cl)c2)s1
    InChI InChI=1S/C20H18ClN3O2S/c1-10-4-6-13(8-15(10)21)24-20-18(12(3)23-24)14(9-17(25)22-20)19(26)16-7-5-11(2)27-16/h4-8,14H,9H2,1-3H3,(H,22,25)
    Molecular weight 399.08 Da
    AlogP 4.821160000000003
    HBond acceptors 5
    HBond donors 1
    Atoms 45

    References

    Publications

    Cross References

    canSAR: 7719229 PubChem: 135986215

    Expert Reviews

    by SERP
    (on 6 Apr 2026)
    Cellular Use Rating
    While no IC50 value is reported, the inhibition of current in HEK293 cells expressing SLC26A9 is much weaker (Figure 5F) than in the LN215 cellular assay. Similarly, the authors suggest a role of SLC26A9...
    by SERP
    (on 17 Apr 2026)
    Cellular Use Rating
    (The reviewer did not leave any public comments)
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