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RW-78

RW-78 : Inhibitor of SIRT2

Structure

Information

  • SIRT2
  • Inhibitor
  • 1 µM

In Vitro Validations

Uniprot ID: Q8IXJ6
Target Class: Epigenetic
Target SubClass: HDAC (Class III)
Potency: IC50
Potency Value: 26 nM
Potency Assay: Standard fluorescence-based assay.
PDB ID for probe-target interaction (3D structure): 9S46
Target aliases:
NAD-dependent protein deacetylase sirtuin-2, SIR2L ...

DOI Reference: 10.1039/D5MD00144G

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:
Subtype selective towards SIRT2. IC50 values for SIRT1, 3 and 5 are above 50 µM
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SERP ratings and comments

No SERP comments found for RW-78