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RUVBL-IN-18 | RUVBL-IN-18 : Inhibitor of RUVBL1, RUVBL2
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
RUVBL1
    • EC50:12 nM
    • EC50:20 nM
    • EC50:9 nM
    RUVBL2
        Inhibitor
        up to 300 nM

        Selectivity

        In Cell Selectivity Assessment
        Potency Assay Off-Target:
        A mini-panel of MYC-Hi and MYC-Lo cell-lines was selected for treatment with RUVBL inhibitor 18 base ...
        Selectivity Assessment Description:
        Viability assessments demonstrated that compound 18 exhibited greater potency than both CB-6644 and ...

        Potency
        Cellular
        In Vitro

        RUVBL1

        Mode of Action: Inhibitor

        Structure-Activity-Relationship data available? No

        DOI Reference: 10.1021/acs.jmedchem.5c03692

        RUVBL2

        Mode of Action: Inhibitor

        Structure-Activity-Relationship data available? No

        DOI Reference: 10.1021/acs.jmedchem.5c03692

        In Vivo Validations

        Mouse
        Dose: 10 mg/Kg
        Route of delivery: Intravenous

        DOI Reference: 10.1021/acs.jmedchem.5c03692

        Orthogonal Probes def

        CB-6644

        Chemical Information

        Coming Soon...

        References

        Publications

        Cross References

        Expert Reviews

        No SERP comments found for RUVBL-IN-18

        Probe RUVBL-IN-18 is in the process of SERP review.

        Please continue to check back for new reviews and commentary.