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RUSKI-201 | Inhibitor of HHAT
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
HHAT
  • IC50:200 nM
  • IC50:730 nM
up to 10 uM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
RUSKI-201 did not inhibit reporter signal in several Shh-pathway independent assays of a Gli-reporte ...

Potency
Cellular
In Vitro

HHAT

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acschembio.6b00896

Chemical Information

Molecular Formula C20H27N3OS
SMILEs CCC(C)CNCC(=O)N1CCc2sccc2C1c1cccc(C)n1
InChI InChI=1S/C20H27N3OS/c1-4-14(2)12-21-13-19(24)23-10-8-18-16(9-11-25-18)20(23)17-7-5-6-15(3)22-17/h5-7,9,11,14,20-21H,4,8,10,12-13H2,1-3H3
Molecular weight 357.19 Da
AlogP 3.561320000000003
HBond acceptors 4
HBond donors 1
Atoms 52

Vendors

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Expert Reviews

by SERP
(on 28 Aug 2020)
Cellular Use Rating
Users should note the following limitations: (1) there is still limited SAR reported surrounding the RU-SKI series (e.g., there is no inactive control analog suggested that I am aware of), (2) this...
by SERP
(on 5 Sept 2020)
Cellular Use Rating
Users of this compound should be aware that this is a diastereoisomeric mixture besides a conformational mixture of E and Z amide. The invitro and in cell data are produced on this mixture.
by SERP
(on 12 Oct 2020)
Cellular Use Rating
(The reviewer did not leave any public comments)
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