RSL3 : Inhibitor of GPX4
Protein target names: GPX4
Mechanism of action: Inhibitor
In Vitro Validations
Uniprot ID: P36969
Target Class: Lipid metabolism
Target SubClass: Glutathione Peroxidase
Potency Value: 111 nM
Potency Assay: RSL3 was evaluated for binding using Microscale thermophoresis (MST) with labelled His-tagged GPX4(U46C) protein. The Kd is defined as the concentration of ligands at which the binding site on GPX4 protein is half occupied.
PDB ID for probe-target interaction (3D structure): --
Structure-activity relationship: Only the (1S,3R) isomer was able to induce death in BJeHLT cells. The (1R,3R) isomer is considered to be inactive.
Phospholipid hydroperoxide glutathione peroxidase, ...
In Cell Validations
In Vivo Data
I have extra information to add