Inhibitor of HDAC3
Protein target names: HDAC3
Mechanism of action: Inhibitor
In Vitro Validations
Uniprot ID: O15379
Target Class: Epigenetic
Target SubClass: HDAC
Potency Value: 0.08 uM
Potency Assay: Substrate-dependent biochemical assays (Reaction Biology). Extensive biochemical characterization has been published on a related compound 106 (Chem Biol. publication): HDAD3 Ki= 14 nM; IC50 with recombinant HDAC3=0.79 uM.
PDB ID for probe-target interaction (3D structure): --
Structure-activity relationship: Yes, several compounds on the pimelic diphenylamide scaffold have been reported with variable activity and specificity for HDAC proteins (see PLoS One report).
Histone deacetylase 3, HDAC3, HDAC3_HUMAN, HD3, SM ...
In Cell Validations
In Vivo Data
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