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QC6352 | Inhibitor of KDM4C
RATINGS:
Cellular Use: (5 reviews)

In Model Organisms: (5 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
KDM4C
  • IC50:35 ± 8 nM
  • EC50:3.5 ± 1 nM
  • EC50:1.3 ± 0.3 nM
up to 100 nM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50 - KDM4B 56 ± 6 nM, KDM4D 104 ± 18 nM, KDM4A 104 ± 10nM

Selectivity Assessment Description:
Enzymatic activity (IC50 nM) KDM2B >4,000; KDM4C 35 ± 8; KDM3A >4,000; KDM4D 104 ± 18; KDM3B >4,00 ...
In Cell Selectivity Assessment
Selectivity Assessment Description:
IMR-90 EC50 >30 uM

Potency
Cellular
In Vitro

KDM4C

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acsmedchemlett.7b00220

In Vivo Validations

Mouse
Dose: 5 , 10, 25, 50 mg/Kg
Route of delivery: Intravenous, Oral
Systemic clearance: 6.9 mL/min/kg (IV)

DOI Reference: 10.1021/acsmedchemlett.7b00220

Chemical Information

Molecular Formula C24H25N3O2
SMILEs CN(c1ccccc1)c1ccc2c(c1)CCC[C@H]2CNc1cnccc1C(=O)O
InChI InChI=1S/C24H25N3O2/c1-27(19-8-3-2-4-9-19)20-10-11-21-17(14-20)6-5-7-18(21)15-26-23-16-25-13-12-22(23)24(28)29/h2-4,8-14,16,18,26H,5-7,15H2,1H3,(H,28,29)/t18-/m0/s1
Molecular weight 387.19 Da
AlogP 5.079700000000004
HBond acceptors 5
HBond donors 2
Atoms 54

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the Portal.

Expert Reviews

by SERP
(on 14 Dec 2020)
Cellular Use Rating
In Model Organisms
The compound represents an important advancement in the field, as it is a potent and selective probe molecule appropriate for both in vitro and in vivo work. Compound shows potent antiproliferative...
by SERP
(on 14 Dec 2020)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
by SERP
(on 18 Dec 2020)
Cellular Use Rating
In Model Organisms
QC6352 is a chemical probe that inhibits KDM4 family members (KDM4A, KDM4B, KDM4C, and KDM4D) with good specificity within the Jumonji demethylase family. It has been characterised in cancer cell lines...
by SERP
(on 6 Oct 2026)
Cellular Use Rating
In Model Organisms
This review was requested following the publication of important new data (Sterling et al, 2026) prompting a re-evaluation of QC6352, which was previously highly recommended as a chemical probe for KDM4C....
by SERP
(on 12 Oct 2026)
Cellular Use Rating
In Model Organisms
A recent study published in Nature Chemical Biology (https://www.nature.com/articles/s41589-026-02306-x) demonstrated that QC6352 potently inhibits DHODH, an essential enzyme in the de novo pyrimidine...

Portal Comment - Important Update

A recent study by Sterling, Holtsmark et al. (Nature Chemical Biology, 2026) identifies QC6352 as a dual KDM4–DHODH inhibitor, with potent DHODH activity. In the glioblastoma models studied, multiple lines...

(last updated: 6 Oct 2026)

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