PNU-120596

PNU-120596 : Type II Positive allosteric modulator of CHRNA7

Structure

SERP Rating

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Information

CHRNA7

Type II Positive allosteric modulator

1 -5 μM

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay, off target (cells): Whole-cell voltage clamp of cDNA injected Xenopus Oocytes.

Probe Selectivity in Cell:

No detectable modulation of human α4β2, α3β4, or α9α10 nicotinic acetylcholine receptors, at 50 μM, 50 μM, and 10 μM ACh stimulation, respectively. DOI: 10.1523/JNEUROSCI.5269-04.2005

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