PFI-653

PFI-653 : Inhibitor of VNN1

Structure

SERP Rating

Probe PFI-653 is in the process of SERP review.

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Information

VNN1

Inhibitor

1 uM

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

MCULE

In Vitro Validations

Uniprot ID: O95497

Target Class: Vanin

Target SubClass: Biotinidase

Potency: IC50

Potency Value: 6.85 nM

Potency Assay: Human recombinant VNN1 assay with 25 pM VNN1

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Pantetheinase, VNN1, VNN1_HUMAN, Vanin-1, Vascular ...

Other Reference: not yet published

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selectivity within target family - Nitrilase family selectivity: BTD (Biotinidase): IC50 > 50 µM (>7000 fold). Selectivity outside target family - Protease panel (Reaction Biology Corp.) (63 proteases) at 1 µM: all < 10 % inhibition Invitrogen kinase panel (483 kinases) at 1 µM and Km ATP: all < 30 % inhibition. CEREP panel (66 enzymes, receptors, and ion channels) at 10 µM: all < 25 % inhibition. PDE panel: all IC50 >30 µM.

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SERP ratings and comments

No SERP comments found for PFI-653