PFI-1
Antagonist of BRD2, BRD4, BRD3, BRDT
Structure
In Cells
In Model Organisms
Information
Protein target names: BRD2, BRD4, BRD3, BRDT
Mechanism of action: Antagonist
In Vitro Validations
DOI Reference: 10.1158/0008-5472.CAN-12-3292
DOI Reference: 10.1158/0008-5472.CAN-12-3292
In Cell Validations
In Vivo Data
No in Vivo Validations
Reagent authentication certificate:
SERP ratings and comments
SERP Ratings
Comments:
This probe meets minimal criteria for use in both cellular and in vivo assays.
Plasma protein binding information relevant to its use: PFI-1 displayed an IC50 of 1.89 uM (n=6) in LPS-stimulated PBMCs with an IL-6 readout, using RPMI media containing 5% FBS (see PMID: 23095041).
(last updated: 18 May 2016 )
SERP Ratings
Comments:
This probe meets SGC probe criteria.
(last updated: 22 Jun 2016 )
SERP Ratings
(last updated: 3 Jan 2017 )