ATP-competitive inhibitor of CSNK1E
In Vitro Validations
Uniprot ID: P49674
Target Class: Protein kinase
Target SubClass: CK1
Potency Value: 32 nM
Potency Assay: In vitro kinase assay
PDB ID for probe-target interaction (3D structure): --
Casein kinase I isoform epsilon, CSNK1E, KC1E_HUMA ...
In Cell Validations
In Vivo Data
Off-Target Selectivity Assesments
Potency end-point : IC50 CSNK1D 711 nM
Potency assay (off target): In vitro kinase assay; 50 additional kinases were tested at 1 and 1 uM. PF-4800567 inhibited 69% of EGFR activity at 1 uM and 83% at 10 uM.
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