PF-4181366

Inhibitor of PDE9A

Structure

Information

  • PDE9A
  • Inhibitor

In Vitro Validations

Uniprot ID: O76083
Target Class: Nucleic acid metabolism
Target SubClass: Phosphodiesterase
Potency: IC50
Potency Value: 1.8 nM
Potency Assay: Enzymatic assay using recombinant proteins
PDB ID for probe-target interaction (3D structure): --
Target aliases:
High affinity cGMP-specific 3',5'-cyclic phosphodi ...

DOI Reference: 10.1021/jm9015334

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Off Target: PDE1C
Potency end-point : IC50 50 nM
Potency assay (off target): Enzymatic assay using recombinant proteins
Probe Selectivity in Vitro:
PDE2 >1000 nM; PDE3A >1000 nM; PDE4C >1000 nM; PDE5 349 nM; PDE6 127 nM; PDE7B >1000 nM; PDE8B >1000 nM; PDE10 >1000 nM PDE11 >1000 nM
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SERP ratings and comments


No SERP comments found for PF-4181366