Bryan Knuckley

University of North Florida

Bryan Knuckley is a Professor and Chair in the Department of Chemistry & Biochemistry at the University of North Florida (UNF). His research is centered on developing innovative methodologies to uncover the substrate specificity of the Protein Arginine Methyltransferase (PRMT) family of enzymes. This work holds profound implications for understanding the dual roles these enzymes play in both normal physiological processes and in the context of pathological conditions such as cancer.

With his work on these enzymes, Bryan has made significant contributions by developing novel tool compounds that serve as valuable instruments for researchers striving to unveil the physiological and pathological roles of PRMT enzymes in cancer. Additionally, his research has paved the way for the creation of specific peptoid-based PRMT inhibitors, which show promise as pharmaceutical-lead compounds for the treatment of cancers.

Bryan Knuckley's academic journey began with a post-doctoral fellowship in the lab of Dr. Thomas Kodadek at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, formerly known as Scripps Florida. He earned his doctoral degree in Chemistry from the University of South Carolina, under the mentorship of Dr. Paul Thompson.

Notably, Bryan's commitment to education and mentorship has been recognized through several awards, including the UNF Outstanding Mentor of the Year and the UNF Outstanding Undergraduate Teaching Award.