OTSSP167
OTSSP167: ATP competitive inhibitor of MELK
Structure
In Cells
In Model Organisms
Probe OTSSP167 is in the process of SERP review.
Please continue to check back for new reviews and commentary.
SERP ratings and comments
SERP Ratings
SERP Comments:
Broad kinase selectivity data is not available for this compound.
(last updated: 6 May 2016 )
SERP Ratings
SERP Comments:
Recently reported selectivity data show that this is not a selective MELK inhibitor (http://www.kinase-screen.mrc.ac.uk/screening-compounds/594372). Based on the selectivity data, I do not recommend this compound as a probe to use in cells or model organisms even though this molecule has entered into Phase 1 clinical trials. OTSSP167 abrogates mitotic checkpoint through inhibiting multiple mitotic kinases (http://dx.doi.org/10.1371/journal.pone.0153518).
(last updated: 16 May 2016 )