OTSSP167
Inhibitor, ATP competitive of MELK
Structure
In Cells
In Model Organisms
Probe OTSSP167 is in the process of SERP review.
Please continue to check back for new reviews and commentary.
Information
Protein target names: MELK
Mechanism of action: Inhibitor, ATP competitive
In Vitro Validations
In Cell Validations
In Vivo Data
SERP ratings and comments
SERP Ratings
Comments:
Broad kinase selectivity data is not available for this compound.
(last updated: 6 May 2016 )
SERP Ratings
Comments:
Recently reported selectivity data show that this is not a selective MELK inhibitor (http://www.kinase-screen.mrc.ac.uk/screening-compounds/594372). Based on the selectivity data, I do not recommend this compound as a probe to use in cells or model organisms even though this molecule has entered into Phase 1 clinical trials. OTSSP167 abrogates mitotic checkpoint through inhibiting multiple mitotic kinases (http://dx.doi.org/10.1371/journal.pone.0153518).
(last updated: 16 May 2016 )